Preparation and evaluation of Lu-177phytate Complex for Radiosynovectomy

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چکیده

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Preparation and quality control of Lu-chitosan for radiosynovectomy

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Preparation and quality control of 177Lu-chitosan for radiosynovectomy

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...

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Development of 177Lu-phytate Complex for Radiosynovectomy

OBJECTIVE(S) In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. MATERIALS AND METHODS Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). The product was converted into chloride form which was further used for labeling of (177)Lu-phytate complex...

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ژورنال

عنوان ژورنال: World Journal of Nuclear Medicine

سال: 2014

ISSN: 1450-1147

DOI: 10.4103/1450-1147.138570